heh, so typical of this thread's build to get derailed
Ibogaine from what i heard in 2006 potentially resets receptor sites in the brain & if the datas correct causes the excess receptors developed throughout the addiction process to shed in a drastically short period of time as opposed to the standard 6+months.
Quote:
(1) Novascreen, Oceanix Biosciences, 21214 Hanover, MD, USA
(2) Present address: Exploratory Medicinal Chemistry, Pfizer Central Research, 06340 Groton, CT, USA
Received: 29 June 1994 Revised: 29 September 1994
Abstract The indole alkaloid ibogaine (NIH 10567, Endabuse) is currently being examined for its potential utility in the treatment of cocaine and opioid addiction. However, a clearly defined molecular mechanism of action for ibogaine's putative anti-addictive properties has not been delineated. Radioligand binding assays targeting over 50 distinct neurotransmitter receptors, ion channels, and select second messenger systems were employed to establish a broad in vitro pharmacological profile for ibogaine. These studies revealed that ibogaine interacted with a wide variety of receptors at concentrations of 1–100 µM. These included the mu, delta, kappa, opiate, 5HT2, 5HT3, and muscarinic1 and 2 receptors, and the dopamine, norepinephrine, and serotonin uptake sites. In addition, ibogaine interacted withN-methyl-d-aspartic acid (NMDA) associated ion and sodium ion channels as determined by the inhibition of [3H]MK-801 and [3H]bactrachotoxin A 20-agr-benzoate binding (BTX-B), respectively. This broad spectrum of activity may in part be responsible for ibogaine's putative anti-addictive activity.
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Theirs soo much potential already with our still primitive tools & techniques in this field. It'd just be better for all the soldiers who suffer in the "war on drugs" daily at the hands of the gov. if it was tapped sooner then later.
Quote:
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I found it the most hard-core psychedelic I'd ever done... and it lasts 24 hours compared to say Amazonian Ayhuasca that's 8-12 at most!!
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Great comparison by all means but
back in my day i had a rather earth shattering experience with a large dose of LSD(Im sure many can relate & have experienced first hand), the drug's duration usually lasts around 8hours. However, the sheer volume of the dose had my ego shattered in what one could define as a ++++; I didn't return to the ego & my body for a good 20+hours & wasn't 95%back until 48 or so hours had passed and i had slept for a while(the other 5% unaccounted for). Opiate receptors had been reset by this experience on a major scale; IMO(in my opinion) ibogaine isnt 100% unique in that sense.
I still remember that nasty back firing neuron frying feeling of the come down.
in short: certain substances if ingested in a high doses will extend duration drastically and others may only add intensity to standard duration.
I feel its baffling just how much we DONT know about how the brain is using these compounds. Their is much speculate & some evidence they play roles in Death & dreams.
I've moved on from using drugs to numb out & stopped using psychedelics which seem to be a polar opposite to "numbing out" since its over amplifying every feeling & beyond quiet literally by overloading the synapse with those back crazy firing neurons giving non existing sensory output etc.
psychedelics, i feel i've learned all i could have hoped to at this point from those teachers. Humans can access those dimensions naturally but much less diluted though meditation & spiritual means.
Love & Light,