Snippets from:
http://www.fibroid101.com/dose.htm
by Elizabeth Smith, M.D.
John Lee, M.D. treats uterine fibroid tumors ( myoma ) with 40 mg/day of natural progesterone for the first 2-3 months. After the uterus reverts to normal, then he maintains the patient on 20 mg/day. The ovary usually produces 20 mg/ of progesterone. During pregnancy, the placenta produces 400 mg/day of progesterone. Thus, there is a very large therapeutic range for the use of progesterone. Natural progesterone is quite safe to use in doses from 20 mg/day to 400 mg/day. Natural Progesterone is the same molecule that your body produces. In contrast, many of the synthetic estrogens and progestins are chemically modified from the natural molecule and are dangerous to use. See Progestins. Thus, Natural Progesterone is safe for you to use in a very large varying dose.
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Summary
* Use a progesterone cream that gives you 40 mg/day of natural progesterone per day for the first 2-3 months
* If the progesterone cream/oil contains 500 mg/day, for the first 2-3 months use two ounces of cream per month; this is about one (1) teaspoon per day.
* If the progesterone cream/oil contains 500 mg/day, after the uterus reverts to normal after 3-12 months, use one ounce of cream per month to maintain a healthy uterus.
* Apply the cream during the two weeks before menses for 14 days if premenopausal (before menopause)
* Apply the cream/oil for three weeks on and one week off if postmenopausal (after menopause)